普洛药业股份有限公司

普洛藥業
DS Technology Platforms
Flow Chemistry Synthetic Biology & Biocatalysis Crystallization & Particle Engineering Peptide High Potency Compound Conjugate Library Service Oligonucleotide Synthesis Preparation & Purification
Conjugate Library Service Platform
Apeloa Conjugate Library Service Platform offers comprehensive services for the development of targeted protein degradation therapeutics, including PROteolysis Trgeting Chimeras (PROTACs). With over 80 PROTAC-focused scientists and two dynamic chemistry service teams located in Boston and Hengdian, the platform provides expertise throughout the entire PROTAC development process. From target validation, hit generation, lead optimization, to clinical development, Apeloa leverages its integrated parallel synthesis platform, extensive E3 ligand, linker, and POI binder intermediate libraries, and strong analytical and ADME capabilities to drive PROTAC projects forward efficiently.
普洛藥業
Team
Apeloa Conjugate Library Service Platform is led by a team of highly experienced scientists, including co-inventors of two approved NDAs and one Phase II IND. The team comprises 12 Ph.D. holders with a combined synthetic chemistry experience of over 100 years, and a tot
Services
● Design, synthesis, and optimization of PROTAC molecules ● Synthesis and optimization of E3 ligands, linkers, and POI binders ● Rapid construction of early screening intermediate libraries via parallel synthesis platform ● Analytical, purification, and ADME evaluation studies ● Non-GMP and GMP scale-up production services
Equipment
●400Hz/600Hz NMR (Bruker/Avance) ●LC-Q-TOF (Agilent) ●LC-MSMS (Shimadzu/Waters/Agilent) ●GC-MSMS (Agilent/Shimadzu) ●HPLC (Waters) ●XRD (Rigaku) ●ICP-MS (Perkin Elmer)
Advantages 1
Advantages 2
Advantages 3
Advantages 4
Advantages 5
普洛藥業
Extensive Intermediate Library
● Over 300 E3 ligands and ligand-linker conjugates in stock ● Expedites PROTAC synthesis and screening
普洛藥業
Flexible E3 Ligand and Linker Combinations
● Facilitates optimization of degradation efficiency and physiochemical properties
普洛藥業
Efficient Parallel Synthesis Platform
Rapid construction of intermediate libraries for early screening
普洛藥業
Expertise in E3 Ligand Scale-up
● Optimized synthetic routes for key clinical PROTAC ligands (e.g., Kymera CRBN, ARV-471, ARV-110) ● Improved yields, reduced costs, and addressed challenges like epimerization
普洛藥業
Retrosynthetic Approach for PROTAC Synthesis
● Avoids epimerization and purification challenges ● Utilizes easy-to-purify fragments and conjugate intermediates
车鸽二手车| 北京嘉和一品餐饮管理有限公司| 盒马| Soundcore 声阔| 金运KINYO| 绝味食品| 六只脚| 车享| 广州卓优二手车| 广州神润二手车| 丰车科技| 餐饮食材网-食品超市-当餐美食_生鲜食品-有机食物-餐饮供应链| 车e估| 检车家| 周黑鸭| 九毛九| 广东省二手车出口综合服务平台| 大公二手车交易中心| 金鱼塘官网| 广州酒家官方网站| 天天拍车| 广州素猫餐饮股份有限公司| 友人户外_友人户外拓展| 汇川技术| 闻泰科技股份有限公司| SANSUI 山水汽车音响| 威武| 东凌控股集团有限公司| 批批车| 车300| 普洛药业股份有限公司| SWAN| 西子湖畔| 遇见小面| 广州市恒安饮食管理有限公司| 长隆旅游度假区| 天朗音响| 淘车车| 粤陈记粥底海鲜火锅| 85度C。咖啡。蛋糕。烘焙專賣店| 永和大王(全国连锁快餐企业)| 广州人上人拓展| 五爷拌面连锁品牌官网| 英歌魂HERO·TEA_官网| HEYTEA - Originator of New Style Tea| 阿遇烧烤| 拉丁餐厅 - 巴西烤肉自助连锁| 冒胖子| 广顺兴| 学而思官网| 作业帮官网 在线教育引领者| 鑫嘉固官网-灌浆料|CPC防碳化涂料|建筑胶结剂|河南嘉固建材有限公司生产厂家| 红黄蓝教育机构| 啄木鸟教育| 千锋教育| 火星时代教育| 【猎聘】-招聘_找工作_求职_企业招人平台| 有缘网-有缘网官方网站| 陌陌官网| 阿姨来了| 广州方邦电子股份有限公司| 无忧精英网| 合肥市华宇半导体有限公司| 广州鑫富物流有限公司| 中天龙(广州)贸易有限公司| 广州华研精密机械股份有限公司|